Southampton secure a win against Manchester City.
Adams, who joined the Club from Birmingham City last July, lobbed goalkeeper Ederson with a first-time strike from 40 yards out after Zinchenko had lost possession in midfield.
City manager Pep Guardiola made six changes to the side which thrashed champions Liverpool 4-0 at Etihad Stadium on Thursday, with key playmaker Kevin de Bruyne among those initially rested.
The goal drew an intense reaction from City, as Fernandinho hit the post and the in-form Alex McCarthy kept out David Silva’s header in the aftermath.
There was to be no repeat of City’s comeback to win the reverse fixture 2-1 in November and defeat leaves Guardiola’s side 23 points behind Liverpool, who beat Aston Villa 2-0 earlier on Sunday.